The pentose phosphate pathway (PPP) is a major glucose catabolism pathway that directs glucose flux to its oxidative branch and leads to the production of a reduced form of nicotinamide adenine dinucleotide phosphate and nucleic acid. Pentose phosphate pathway. Krebs (citric acid) cycle and oxidative phosphorylation. Transcription factor NRF2 [NFE2L2, nuclear factor (erythroid-derived-2)-like 2] is known as a major sensor of oxidative stress in the cell. This pathway, which requires the presence of oxygen, is called pentose phosphate pathway (PPP) or hexose monophosphate shunt (HMS). Is the Pentose Phosphate Pathway just about making ribose sugars from glucose? pentose-phosphate pathway hexose monophosphate shunt phosphogluconate pathway O SlideShare utiliza cookies para otimizar a funcionalidade e o desempenho do site, assim como para apresentar publicidade mais relevante aos nossos usuários. The NADPH is required for biosynthetic reactions such as fatty acid synthesis, cholesterol synthesis, drug reduction, and as a cofactor for some non-synthetic enzymatic reactions. The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. 9.25). sugars) via the Pentose Phosphate Pathway. Our mission is to provide a free, world-class education to anyone, anywhere. Up Next. (1) Important for biosynthetic pathways using NADPH, and (2) a high cytosolic reducing potential from NADPH is sometimes required to advert oxidative damage by radicals, e.g., O 2-and H—O Pentose phosphate pathway activation has been suggested as a mechanism by which dysregulated NRF2–KEAP1 signaling promotes cellular proliferation and tumorigenesis . Cellular respiration introduction. Cellular respiration introduction. Sort by: Top Voted. The direct degradation of glucose is achieved in two phases: The first one consists of the oxidative conversion of glucose-6-P to pentose phosphates and the second non-oxidative phase involves the regeneration of glucose-6-phosphate from pentose phosphate, while glucose-6-phosphate enters the cycle again (Fig. The oxidative pentose phosphate pathway converts between 15 and 30% of hexose phosphate to glyceraldehyde-3-phosphate and CO 2 in pea and spinach chloroplasts. There are two different phases in the pathway. The pentose phosphate pathway is also important in the red blood cell, where NADPH is required to maintain an adequate pool of reduced glutathione, which is used to remove hydrogen peroxide.. As shown in Figure 5.15, the tripeptide glutathione (y-glutamyl-cysteinyl-glycine) is the reducing agent for glutathione peroxidase, which reduces H2O2 to H2O and O2. Carbohydrate metabolism questions. Pentose Phosphate Pathway Generation of NADPH and Pentoses Overview Function NADPH production Reducing power carrier Synthetic pathways Role as cellular antioxidants ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on - id: 3b5ef9-MzQ0M The Hexose Monophosphate Shunt is also known as “Pentose Phosphate Pathway” (PPP).This is an alternative Glucose oxidation pathway.The hexose monophosphate pathway is used for the production of NADPH from NADP.. The PPP serves a vital role in regulating cancer cell growth and involves many enzymes. Next lesson. Glucose-6-phosphate dehydrogenase and a lactonase catalyze the first committed step of the oxidative pentose phosphate pathway which is a strategic control point.

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