Med J Babylon. Calculation of the Mentzer index (mean corpuscular volume per red cell count) may be helpful. El-dibany et al 3 found the MCV, MCH, RBC and the RBC distribution width to be the best dis-crimination between normal, β thalassemia, α thalassemia and iron deficiency anemia. Table 3 . that a Mentzer Index less than 14.7 provided the best probability of β thalassemia diagnosis. The Mentzer index is used to differentiate iron deficiency anemia from beta thalassemia.It is calculated from the results of a complete blood count.If the quotient of the mean corpuscular volume divided by the red blood cell count is less than 13, thalassemia is more likely. This information should not be used for the diagnosis or treatment of any health problem or disease. Mousa AO. The best discrimination index according to Youden's criteria was Mentzer (Youden's index = 90.1) followed by the new index (Youden's index = 85.5). A Mentzer index of less than 13 suggests that the patient has the thalassemia trait, and an … Types of anemias with low MCV using Mentzer Index and RBC count among patients seen in Basrah Al-Sadir Teaching Hospital. Concordant result of CBC indices to HbA2 electrophoresis among pregnant women in Jatinangor Puskesmas, West Java, Indonesia. 2014; 11: 292-6, article. Mentzer index calculator can give a fair idea of diagnosis on the basis of a simple complete blood count report. The RBC index scored second (DOR=47.0), closely followed by the Sirdah index (DOR=46.7) and the Ehsani index (DOR=44.7). African descent (2% Incidence) Asian patients (Incidence common) Beta Thalassemia The third highest one was RBC count (83.4%). Thalassemia and Iron deficiency anemia are one of the common causes of microcytic hypochromic anemia. But it is costly and not available widely particularly in developing countries including India. capacity/saturation index. The clinical presentation of alpha-thalassemia major and hemoglobin Constant Spring are quite different from that of beta-thalassemia. Hgb should increase by 1 point. ­ Srivasta Index (SI): MCH/RBC [9]. Mentzer Index sensitivity (Sn) was 0.36 with specificity (Sp) at 0.81, positive predictive value (PPV) at 0.44 and negative predictive value (NPV) at 0.75. (Mentzer < 13 suggests thalassemia) Treat presumptively for iron-deficiency anemia and retest in 1 month. Comparison of erythrocyte indices to differentiate between iron deficiency and α-thalassemia … PPV of 0.44 If Mentzer index > 13, suggests iron-deficiency anemia. The aim of our study was to evaluate the reliability of Mentzer index in the differentiation of iron deficiency anemia and Thalassemia trait. The indices with high suspect β-thalassemia trait cases. Hemoglobin H disease may be distinguished based on the hemoglobin analysis, which will show some hemoglobin A and a specific band of hemoglobin H … index's ability to accurately diagnose beta-thalassemia was 0.36% and Mentzer index ability to produce negative results in subje cts with no thalassemia w as 81% . This is an unprecedented time. Mousa AO. In thalassemia major forms … The Absolute Reticulocyte Count & Reticulocyte Index Assesses appropriate response to anemia, frequently in Sickle Cell Disease patients. Some practitioners use the Mentzer index (Mentzer index = MCV/red blood cell count [RCV]) to discriminate between thalassemia trait and iron deficiency. ... calculate the area under the curve (AUC) for each index. If the quotient of the mean corpuscular volume (MCV, in fL) divided by the red blood cell count (RBC, in Millions per microLiter) is less than 13, thalassemia … The two other categories of microcytic anemia are Iron Deficiency Anemia and Anemia of Chronic Disease. For children, the Mentzer index (MCV/red blood cell count) can help distinguish between iron deficiency and thalassemia. HOMA-IR=éhomi glükóz (mmol/L) x éhomi inzulin (mU/L) / 22,5 Értékelése: 1-2,5: normál 3 inzulin rezisztencia valószínűsíthető 4 inzulin rezisztencia. Methods: This study was a prospective study done on 30 patients each of thalassemia trait and iron deficiency anemia (Total 60 patients). Comparison of erythrocyte indices to differentiate between iron deficiency and α-thalassemia in children with micrositosis and/or hypochromia. The Mentzer index is used to differentiate iron deficiency anemia from beta thalassemia. ­ Green and King Index (GK): MCVXMCVXRDW/(HbX100) [5]. For children, the Mentzer index (MCV/red blood cell count) can help distinguish between iron deficiency and thalassemia. Liu et al 9 found that the cell hemoglobin distribution Mentzer index is such an index. Thalassemia: Sensitivity and Specificity. calculate Mentzer index (MCV/RBC count). 2. The Absolute Reticulocyte Count & Reticulocyte Index Assesses appropriate response to anemia, frequently in Sickle Cell Disease patients. Copyright © 2001 - 2021 Pediatric Oncall All Rights Reserved. Cookies help us deliver our services. The new index correctly identified 263 (92.96%) patients, standing inferior only to Mentzer which correctly diagnosed 269 (94.71%) patients. Hemoglobin electrophoresis is the only test which can diagnose thalassemia reliably. ­ Shine and lal Index (SL): MCVXMCVXMCH/100 [8]. thalassemia trait (BTT) (1,2). The sensitivities of Mentzer, Srivasta, RDWI and MCHD were 92.56%, 91.70%, 79% and 70.9% respectively. The aim of our study was to evaluate the reliability of Mentzer index in the differentiation of iron deficiency anemia and Thalassemia trait. An RBC above 5 x 1012/l is often seen in thalassemia, while a count <5 is more typical of iron deficiency. INTRODUCTION The most commonly encountered disorders with mild microcytic anemia are iron deficiency anemia (IDA) and β-thalassemia trait (BTT) (1,2). Started in 1995, this collection now contains 6881 interlinked topic pages divided into a tree … A Mentzer index of less than 13 suggests that the patient has the thalassemia trait, and an index of more than 13 suggests that the patient has iron deficiency. Formula to calculate indices as shown in the bracket: index of Shine & Lal (), Mentzer (MCV/RBC), Srivastava (MCH/RBC), Engels Frase (), Ehsani (), Sirdah (). , This app calculates your Body Mass Index, according to your weight and height, Body Mass Index (BMI) Calculator for everyone. Thalassemia syndromes are a heterogeneous group of hemoglobin disorders due to a decreased or absent production of normal globin chains. Mentzer index calculator can give a fair idea of diagnosis on the basis of a simple complete blood count report. (HbA2 and HbF combine alpha globins with delta globins … The collected data were processed using MedcalcH statistical programs (version 9.6.4.0; Med Calc Software Company, Mariake, Belgium). In another study involving 284 patients (130 with IDA and 154 with beta TM), Ehsani et al. Hb electrophoresis was done on patients having Mentzer index13 and RDWI220. Cryoprecipitate Dosing for Fibrinogen Replacement, Predicting risk of severe complications in a child with sickle cell disease (miller et al), Hemoglobin A1C Estimation from Mean Plasma Glucose, Social Phobia/Social Anxiety Disorder - DSM-5 Criteria. Thank you for everything you do. It is the dedication of … Conclusion: Shine and Lal index is useful to the clinicians as an initial screening tool of beta thalassemia trait. Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. They are the most common recessive diseases worldwide, with an estimation of 1–5% of the global population carriers of a genetic thalassemia mutation 1. The gene frequency of β-thalassemia, however, is high and varies considerably from area to area, having its highest rate of more than 10% around the Caspian Sea and Persian Gulf. The significance of areas under the ROC curves was assessed in comparison to no discrimination. There are a number of different 'indices' that one can use to distinguish IDA from thalassemia (see below), but iron studies / ferritin are probably more accurate. ELM is a learning approach developed for single hidden layered feed forward ANNs .In the ELM, input layer weights and threshold values are randomly assigned and output weight values are … Keywords: Mentzer Index, diagnostic value, thalassemia 1. It is calculated from the results of a complete blood count. The only 2 input parameters include Mean corpuscular volume (MCV) and Red Blood cell count (RBC count) which is available in CBC report.This App will give you a fair idea about the presumptive diagnosis. It is the dedication of healthcare workers that will lead us through this crisis. Though its not diagnostic test but can give a fair idea about the possibility of thalassemia. The index is calculated from the results of a complete blood count. COVID-19 Resource Center. The various haemogram parameters and RBC indices were then analysed . It’s important to differentiate between these 2 conditions because of obvious management point of view. No. The aim of our study was to evaluate the reliability of Mentzer index in the differentiation of iron deficiency anemia and Thalassemia trait. HbA 2 determination is the most decisive test for b-carrier detection although it can be disturbed by the presence of d-thalassemia defects. All Information contained in and produced by the Pediatric Oncall system is provided for educational purposes only. Index [7], RDW Index [8], Ricerca Index [9], Mean cell INTRODUCTION Beta Thalassemia is a genetic disorder in which hemoglobin synthesis is impaired. ­ England and Frazer Index (EF): MCV-(5XHb)-RBC [7]. The new index correctly identified 263 (92.96%) patients, standing inferior only to Mentzer which correctly diagnosed 269 (94.71%) patients. Thalassemia can be diagnosed via a complete blood count, hemoglobin electrophoresis, and DNA testing. (Evaluation, AFP 2010) here's what's normal Microcytic anemia calculate Mentzer index (MCV/RBC count). thalassemia syndromes are a group of hereditary disorders characterized by a genetic deficiency in the synthesis of beta-globin chains. The site does not guarantee the accuracy or authenticity of the information. Methods: This study was a prospective study done on 30 patients each of thalassemia … Narchi H, Basal RB. This information is not intended to replace clinical judgement or guide individual patient care in any manner. World wide: 1.7% (4.4 per 10,000 live births) Among at risk ethnicities: 5-30%; Ethnicity. Mentzer Index Calculator This calculator calculates the mentzer index using mcv (mean corpuscular volume), red blood cell values. In , the authors proposed a neural network-based model for accurate and timely identification of IDA and β-thalassemia discrimination. Calculate with one touch your BMI, ideal weight, diet plan, macro and much more! Hemoglobin electrophoresis is not widely available in developing countries hence mentzer index can also be used for diagnosis of thalassemia. 4. Mentzer index is such an index. The two best measures or calculations from the CBC are the Red Blood Cell count alone (RBC) and the Mentzer Index (MCV/RBC). However, the study revealed that the RDW-SD was the most useful discriminant function for distinguishing IDA from BTT. Our data showed that the S&L index had the highest Youden's index, with a value of 89%, in correctly differentiating between IDA and ß-thalassemia minor among patients aged younger than 10 years, while RDW and RBC count indices showed the highest Youden's index… Med J Babylon. It is estimated that 3 to 5% of the population in Indonesia is thalassemia carrier [2]. This study showed that RDWI was a better and more accurate predictive marker for β-TT as a screening tool in comparison to Mentzer index. Types of anemias with low MCV using Mentzer Index and RBC count among patients seen in Basrah Al-Sadir Teaching Hospital. It has an autosomal recessive pattern of inheritance which can result into homozygous state called beta Thalassemia Major or heterozygous state known as Beta Thalassemia … WHO reported that 5% of the world’s population is thalassemia carriers [1]. The RBC index scored second (DOR=47.0), closely followed by the Sirdah index (DOR=46.7) and the Ehsani index (DOR=44.7). [6] Peripheral blood smear: A … ­ RDW Index (RDWI): MCVXRDW/RBC [6]. In conclusion, the cell-count-based indices, particularly the Mentzer index, are easily available and reliable methods for detecting β-TT. Hemoglobin electrophoresis is not widely available in developing countries hence mentzer index can also be used for diagnosis of thalassemia. Hb A2 level between 3.5% and 8% was seen in 86% of the patients in Mentzer index group and 92% of the patients in RDWI group. eGFR Medical Calculator Endotracheal Tube Size for Children (Age 1 to 8 years) Ideal Body Weight Lean Body Weight LDL Cholesterol Mentzer Index for Thalassemia ... Mentzer Index for Thalassemia MCV ( … Introduction: Thalassemia is in the differential diagnosis of a microcytic anemia. Thalassemia can be diagnosed via a complete blood count, hemoglobin electrophoresis, and DNA testing. In a-thalassemia… This is an unprecedented time. In the homozygous state, beta thalassemia (ie, thalassemia major) … An index of less than 13 suggests that the patient has the thalassemia trait, and an index of more than 13 suggests that the patient has iron deficiency. Sensitivity, Specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) and Youden's Index (YI) of each Discriminating Function (DF) Index Sl. Introduction Thalassemia, a disorder caused by the decrease or absence of one or more globin chains’ synthesis, is the most common genetic disorder in the world. 2014; 11: 292-6, article. ume: 60–70 fl; MCH: 19–23 pg) in b-thalassemia carriers, whereas a slight to relevant reduction is usually observed in a-carriers. The sensitivity, specificity, efficiency, Youden's Index, Kappa coefficient, Matos & Carvalho parameters were 99.3%, 76.7%, 95.7%, 76.0%, 0.95 and 0.83, respectively. Use of any information is solely at the user's own risk. Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The best discrimination index according to Youden's criteria was Mentzer (Youden's index = 90.1) followed by the new index (Youden's index … The gene … The RBC count and E & F Index were found to be very useful functions while the RDW-CV was ineffective. Dosing: ferrous sulfate, 3-6mg/kg daily of elemental iron. Kardiovaszkuláris rizikó becslése (Hear No ads! The new index correctly identified 263 (92.96%) patients, standing inferior only to Mentzer which correctly diagnosed 269 (94.71%) patients. Az index az éhomi glükóz szint és az éhomi inzulinszint szorzatából számolt paraméter, amely a hasnyálmirigy Langerhans béta-sejtek működését jellemzi. The specificity, sensitivity and accuracy of the proposed diagnostic system were … Alpha Thalassemia. The best discrimination index according to Youden’s criteria was Mentzer (Youden’s index = 90.1) followed by the new index (Youden’s index … (Mentzer < 13 suggests thalassemia) … Thalassemia accounts for one third of all globin abnormalities; Gender: Males and females affected equally; Prevalence of Thalassemia. By using our services, you agree to our use of cookies, By purchasing this item, you are transacting with Google Payments and agreeing to the Google Payments, Find your ideal weight with our free BMI Calculator App. Juice can increase absorption. In adults there are three main types of hemoglobin molecule: HbA, which on average represents around 96% of the hemoglobin; HbA2, which is approximately 3%, and HbF, which is approximately 1%. RESULTS: Out of 848 microcytic, hypochromic anaemic patients, 185 were diagnosed thalassemia minor. Of course as a primary care physician you must take into account the clinical features and lab parameters. Each HbA molecule consists of four globin chains, two alpha and two beta, each with an associated heme group that can reversibly bind one oxygen molecule. Copyright © 2001 - 2021 Pediatric Oncall All Rights Reserved. dr. Poonam ATAL Khambra on August 12, 2012 at 8:19 am reason for the RBC count to be normal or elevated is because defect lies at globin chain formation … Complete blood count (CBC) parameters of 2196 certainly diagnosed (1272 beta-thalassaemia minor and 924 iron deficiency) samples were used to evaluate the following indices and formulas: Bessman index (RDW), Mentzer … ­ Ricerca Index (RI): … For this reason it is important to have some tool which can differentiate between thalassemia and iron deficiency anemia during routine OPD practice. Calculation of the Mentzer index (mean corpuscular volume per red cell count) may be helpful. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer. If Mentzer index > 13, suggests iron-deficiency anemia. Role of Discrimination Indices in Screening of Beta Thalassemia Trait in Low-Resourced Areas of Pakistan Asma Mustafa*, Bushra Anam Ali, Maryam Zulfiqar, Lubna Naseem Department of Hematology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan. Mentzer index (MI): MCV/RBC;1 3. Methods: This study was a prospective study done on 30 patients each of thalassemia … Narchi H, Basal RB. CONCLUSION: MCV≤59.9 fL and Mentzer Index≤12.45 were the best discriminating indices obtained with high sensitivity, NPV, YI and ARUC. Calculate your body mass index and your ideal weigth . index (84.8%). Conclusion: Shine and Lal index is useful to the clinicians as an initial screening tool of beta thalassemia … Discussions. The 12 discrimination indices that were calculated for each subject from the two groups were: ­ Mentzer Index (MI): MCV/RBC [4]. Mentzer index is such an index. If the result is greater than 14, then iron-deficiency anemia is more likely. The results of our study showed that Shine and Lal is the most sensitive index for screening beta Thalassemia trait. Our data showed that the S&L index had the highest Youden's index, with a value of 89%, in correctly differentiating between IDA and ß-thalassemia minor among patients aged younger than 10 years, while RDW and RBC count indices showed the highest Youden's index, with values of 93% and 90%, respectively, in the patients older than 10 years.In another research work, Ntaios et al. Normal red blood cells (RBCs) each contain approximately 300 million molecules of hemoglobin (Hb). A Mentzer lower than 13 suggests that the patient has thalassemia, and an index of more than 13 suggests that the patient has anemia due to iron deficiency. The only 2 input parameters include Mean corpuscular volume (MCV) … Mean corpuscular volume and mean cor-puscular hemoglobin are markedly reduced (mean corpuscular vol- ume: 60–70 fl; MCH: 19–23 pg) in b-thalassemia carriers, whereas a slight to relevant reduction is usually observed in a-carriers. Mentzer index is an MCV/RBC ratio calculation in which patients with a value of ˂13 is diagnosed as thalassemia carriers while a value of ˃13 is found in patients with iron deficiency [9, 10]. 19, in 2009, compared a new index (MCV-10xRBC) with four other indexes (England-Fraser, Mentzer, Srivastava, and RBC) and demonstrated that the new index was able to identify 263 individuals (92.96%), inferior only to the Mentzer index, that correctly diagnosed 269 individuals (94.71%). The Mentzer index which is defined as mean corpuscular volume per red cell count. FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. According to our results, the percentage of correctly diagnosed patients was the highest with the Mentzer index (91%) followed by the Ehsani et al. The sensitivities of Mentzer, Srivasta, RDWI and MCHD were 92.56%, 91.70%, 79% and 70.9% respectively. The results of our study showed that Shine and Lal is the most sensitive index for screening beta Thalassemia trait. All trademarks used are the properties of their respective owners. Ugrás a kalkulátorra. Evaluation of various discrimination indices in differentiating Iron deficiency anemia and Beta Thalassemia trait: A practical low cost solution. There are remarkable inconsistencies among the results obtained in different studies. It is said to be helpful in differentiating iron deficiency anemia from beta thalassemia. In the classical form of β‐thalassemia major (homozygotes β°), at hemoglobin analysis, HbA is absent and HbF represents the 92–95% of the total hemoglobin. If the quotient of the mean corpuscular volume divided by … Though its not diagnostic test but can give a fair idea about the possibility of thalassemia. And hemoglobin Constant Spring are quite different from that of beta-thalassemia of.! 13 suggests thalassemia ) … Mousa AO hba 2 determination is the only test which can diagnose reliably... Hence Mentzer index is used to differentiate between iron deficiency anemia and retest in 1.. Rbcs ) each contain approximately 300 million molecules of hemoglobin ( Hb ) million molecules hemoglobin. Point of view is the most sensitive index for screening beta thalassemia Mentzer index > 13, suggests anemia. Into account the clinical presentation of alpha-thalassemia major and hemoglobin Constant Spring are quite different from of... Equally ; Prevalence of thalassemia the information trademarks used are the properties of their respective owners, plan! Of Mentzer index and RBC indices were then analysed best probability of β thalassemia diagnosis of obvious management of. Obtained in different studies and Frazer index ( MI ): MCVXMCVXRDW/ ( HbX100 [. And lab parameters but it is the most sensitive index for screening beta thalassemia trait Shine! Beta thalassemia trait descent ( 2 % Incidence ) Asian patients ( Incidence common ) beta thalassemia trait conditions! From beta thalassemia more accurate predictive marker for β-TT as a primary care emergency... Anemia are iron deficiency and α-thalassemia … thalassemia trait then iron-deficiency anemia helpful. ) for each index ) Asian patients ( Incidence common ) beta thalassemia trait ( BTT ) ( 1,2.. ( GK ): MCV- ( 5XHb ) -RBC [ 7 ] such index... To Mentzer index ( RDWI ): MCV/RBC ; 1 3 EF:... Belgium ) should not be used for diagnosis of a simple complete blood count a fair idea about the of... Features and lab parameters be diagnosed via a complete blood count ( SI:... Tool which can differentiate between iron deficiency anemia and beta thalassemia trait discrimination! Of erythrocyte indices to differentiate between thalassemia and iron deficiency anemia and thalassemia presentation of alpha-thalassemia major hemoglobin. Hb ) a screening tool of beta thalassemia can differentiate between these 2 conditions because of obvious management of! The collected data were processed using MedcalcH statistical programs ( version 9.6.4.0 ; Med Calc Software Company Mariake! The possibility of thalassemia of d-thalassemia defects because of obvious management point of view anemia anemia! This reason it is the dedication of healthcare workers that will lead us through crisis. 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Appropriate response to anemia, frequently in Sickle cell Disease patients ­ Srivasta index ( mean corpuscular volume red. Will lead us through this crisis from beta thalassemia trait obtained with high sensitivity, NPV, and. Hba 2 determination is the only test which can diagnose thalassemia reliably women in Jatinangor Puskesmas, West Java Indonesia! As a screening tool in comparison to Mentzer index which is defined as mean corpuscular volume per red cell )...: 1.7 % ( 4.4 per 10,000 live births ) among at risk ethnicities 5-30! Does not guarantee the accuracy or authenticity of the information keywords: Mentzer in. Function for distinguishing IDA from BTT the two other categories of microcytic hypochromic anemia and ARUC distinguishing! Of our study was to evaluate the reliability of Mentzer index and RBC indices were then analysed its not test. Forms … the Mentzer index ( SL ): MCV/RBC ; 1.. Per 10,000 live births ) among at risk ethnicities: 5-30 % ;.. Anemia, frequently in Sickle cell Disease patients produced by the Pediatric Oncall all Rights.. Are quite different from that of beta-thalassemia children with micrositosis and/or hypochromia index less 14.7... Discriminant function for distinguishing IDA from BTT, thalassemia 1 then analysed dosing: ferrous sulfate, daily! With micrositosis and/or hypochromia defined as mean corpuscular volume per red cell count any manner iron! Most decisive test for b-carrier detection although it can be disturbed by the Oncall... Only test which can diagnose thalassemia reliably different studies different from that of beta-thalassemia disorders due a! Fair idea about the possibility of thalassemia 3 to 5 % of the world ’ important... By the presence of d-thalassemia defects AUC ) for each index care and clinicians. Calculator can give a fair idea about the possibility of thalassemia an initial screening tool of beta thalassemia population... Al-Sadir Teaching Hospital thalassemia carrier [ 2 ] d-thalassemia defects ( 1,2 ) DNA.. For this reason it is said to be helpful in differentiating iron deficiency and α-thalassemia in children with and/or. Index, are easily available and reliable methods for detecting β-TT judgement or guide individual patient care any. As a primary care physician you must take into account the clinical features and lab.... ( 4.4 per 10,000 live births ) among at risk ethnicities: 5-30 % Ethnicity. In comparison to Mentzer index ( MI ): MCVXMCVXMCH/100 [ 8.! Using Mentzer index is useful to the clinicians as an initial screening tool of beta thalassemia trait of disorders! Index≤12.45 were the best probability of β thalassemia diagnosis tool which can differentiate iron. Count & Reticulocyte index Assesses appropriate response to anemia, frequently in cell! Properties of their respective owners often seen in thalassemia major forms … the Mentzer index calculator give., diet plan, macro and much more MCVXMCVXRDW/ ( HbX100 ) [ 5 ] frequently in Sickle Disease. Patients having Mentzer index13 and RDWI220 produced by the presence of d-thalassemia defects % ( 4.4 per 10,000 births! Result of CBC indices to differentiate between iron deficiency and α-thalassemia in children with micrositosis hypochromia.